Meet The Research Team
The Endocrine Oncology Research Group is lead by Dr. Leonie Young and is based at York House, RCSI, St Stephen’s Green. Dr Young graduated from Trinity College Dublin and completed her PhD training at University College Dublin in 1997
Dr Ann Hopkins is based in the RCSI Education & Research Centre in Beaumont Hospital. Dr. Hopkins received her PhD in Pharmacology from University College Dublin, and spent several years working in the Epithelial Pathobiology Research Unit in Emory University, Atlanta, USA before returning to Ireland in 2004.
“My research is focused on the chromatin protein HMGB2 which interacts with the estrogen receptor and the coregulatory protein SRC-1. Funded by an Irish Research Council for Science, Engineering and Technology INSPIRE Marie Curie fellowship.”
“My current work involves the use of a novel serum biomarker to detect tumour recurrence and monitor the treatment of recurrent tumours using the tyrosine kinase inhibiting drug, Dasatinib. Current grant funding from Science Foundation Ireland.”
JEAN MC BRYAN
“Funded by Science Foundation Ireland, my research focuses on how breast tumour cells adapt to become resistant to aromatase inhibitor drugs which are routinely used to treat oestrogen receptor-positive breast cancer.”
“I am working on a project that investigates mechanisms involved in the development of resistance to Aromatase Inhibitor therapy. Aromatase Inhibitors are currently used to treat oestrogen receptor–positive breast cancer in postmenopausal women.
This project is funded by Science Foundation Ireland (SFI).”
“My research investigates the role of SRC-1 and related proteins in the development of drug resistance and metastasis. Using both traditional lab-based experiments and in vivo mouse models, I am helping develop a novel therapeutic peptide to target breast cancer metastasis. Current grant funding from Science Foundation Ireland.”
“I am currently investigating the role of the p160 protein SRC-1 and transcription factor HOXC11 in endocrine therapy-resistant breast cancer. Funding is provided by Breast Cancer Ireland.”
“My research is focused on investigating associations and interactions between the coregulatory protein SRC-1 and HOXC11 in endocrine therapy-resistant breast cancer.
Current grant funding from Breast Cancer Campaign (UK) and Science Foundation Ireland.”
“My current research involves looking at the interactions between the transcription factor HOXC11 and the oestrogen receptor alpha which are implicated in breast cancer resistance to endocrine therapies. Funding is provided by Breast Cancer Ireland.”
“My research focuses on resistance to aromatase inhibitors and elucidating the pathways involved. Of particular interest are the AIB1 steroid co-regulator and its clinical implications. Moreover, I am working on a theory of a differential oestrogen regulation of its target genes in AI resistance. Current grant funding from Science Foundation Ireland.”
“My research focuses on ADAM22, a newly identified protein in endocrine-resistant breast cancer. I am investigating the functional role of ADAM22 and its potential as a drug target in treating breast cancer.”
“I work with protein co-activators and co-repressors (NCoR and SRC1). I am mostly involved in translational work relating protein expression to impact on patient outcome and response to therapy.”