One of the key strategic initiatives of Breast Cancer Ireland is to support Irish centres of excellence so that we can deliver world-class research, improve patient care and deliver greater long-term development of research infrastructure. The Breast Cancer Ireland Research Centre is located within the Royal College of Surgeons in Ireland and employs 14 full-time scientific researchers and postgraduate medical students. The Breast Cancer Research Centre provides an outstanding research environment with access to cutting edge facilities. It also practices the very best in ‘bench-to-bedside’ translational research with significant international publications as well as establishing why certain patients will develop resistance to current therapies. Through this work, the team aim to identify gene alterations that act as biomarkers (measurable indicators of a biological state or condition). These help improve patient treatment strategies and, ultimately, improve novel drug targets to defeat breast cancer.